Constrained Superfields and Standard Realization of Nonlinear Supersymmetry

A constrained superfield formalism has been proposed recently to analyze the low energy physics related to Goldstinos. We prove that this formalism can be reformulated in the language of standard realization of nonlinear supersymmetry. New relations have been uncovered in the standard realization of nonlinear supersymmetry.Comment: 8+1 pages, Latex, expanded discussions on scalar and vector field

Nonlinear Realization of Spontaneously Broken N=1 Supersymmetry Revisited

This paper revisits the nonlinear realization of spontaneously broken N=1 supersymmetry. It is shown that the constrained superfield formalism can be reinterpreted in the language of standard realization of nonlinear supersymmetry via a new and simpler route. Explicit formulas of actions are presented for general renormalizable theories with or without gauge interactions. The nonlinear Wess-Zumino gauge is discussed and relations are pointed out for different definitions of gauge fields. In addition, a general procedure is provided to deal with theories of arbitrary Kahler potentials.Comment: 1+18 pages, LaTe

Cortical depth dependent population receptive field attraction by spatial attention in human V1

Visual spatial attention concentrates neural resources at the attended location. Recently, we demonstrated that voluntary spatial attention attracts population receptive fields (pRFs) toward its location throughout the visual hierarchy. Theoretically, both a feed forward or feedback mechanism could underlie pRF attraction in a given cortical area. Here, we use sub-millimeter ultra-high field functional MRI to measure pRF attraction across cortical depth and assess the contribution of feed forward and feedback signals to pRF attraction. In line with previous findings, we find consistent attraction of pRFs with voluntary spatial attention in V1. When assessed as a function of cortical depth, we find pRF attraction in every cortical portion (deep, center and superficial), although the attraction is strongest in deep cortical portions (near the gray-white matter boundary). Following the organization of feed forward and feedback processing across V1, we speculate that a mixture of feed forward and feedback processing underlies pRF attraction in V1. Specifically, we propose that feedback processing contributes to the pRF attraction in deep cortical portions

CO observations of water-maser post-AGB stars and detection of a high-velocity outflow in IRAS 15452-5459

Many aspects of the evolutionary phase in which Asymptotic Giant Branch stars (AGB stars) are in transition to become Planetary Nebulae (PNe) are still poorly understood. An important question is how the circumstellar envelopes of AGB stars switch from spherical symmetry to the axially symmetric structures frequently observed in PNe. In many cases there is clear evidence that the shaping of the circumstellar envelopes of PNe is linked to the formation of jets/collimated winds and their interaction with the remnant AGB envelope. Because of the short evolutionary time, objects in this phase are rare, but their identification provides valuable probes for testing evolutionary models. We have observed (sub)millimeter CO rotational transitions with the APEX telescope in a small sample of stars hosting high-velocity OH and water masers. These targets are supposed to have recently left the AGB, as indicated by the presence of winds traced by masers, with velocities larger than observed during that phase. We have carried out observations of several CO lines, ranging from J=2-1 up to J=7-6. In IRAS 15452-5459 we detect a fast molecular outflow in the central region of the nebula and estimate a mass-loss rate between 1.2x10^{-4} Msun yr^{-1} (assuming optically thin emission) and 4.9x10^{-4} Msun yr^{-1} (optically thick emission). We model the SED of this target taking advantage of our continuum measurement at 345 GHz to constrain the emission at long wavelengths. For a distance of 2.5 kpc, we estimate a luminosity of 8000 Lsun and a dust mass of 0.01 Msun. Through the flux in the [CII] line (158 um), we calculate a total mass of about 12 Msun for the circumstellar envelope, but the line is likely affected by interstellar contamination.Comment: 12 pages, 9 figures, accepted for publication on A&

A Method of Drusen Measurement Based on the Geometry of Fundus Reflectance

BACKGROUND: The hallmarks of age-related macular degeneration, the leading cause of blindness in the developed world, are the subretinal deposits known as drusen. Drusen identification and measurement play a key role in clinical studies of this disease. Current manual methods of drusen measurement are laborious and subjective. Our purpose was to expedite clinical research with an accurate, reliable digital method. METHODS: An interactive semi-automated procedure was developed to level the macular background reflectance for the purpose of morphometric analysis of drusen. 12 color fundus photographs of patients with age-related macular degeneration and drusen were analyzed. After digitizing the photographs, the underlying background pattern in the green channel was leveled by an algorithm based on the elliptically concentric geometry of the reflectance in the normal macula: the gray scale values of all structures within defined elliptical boundaries were raised sequentially until a uniform background was obtained. Segmentation of drusen and area measurements in the central and middle subfields (1000 μm and 3000 μm diameters) were performed by uniform thresholds. Two observers using this interactive semi-automated software measured each image digitally. The mean digital measurements were compared to independent stereo fundus gradings by two expert graders (stereo Grader 1 estimated the drusen percentage in each of the 24 regions as falling into one of four standard broad ranges; stereo Grader 2 estimated drusen percentages in 1% to 5% intervals). RESULTS: The mean digital area measurements had a median standard deviation of 1.9%. The mean digital area measurements agreed with stereo Grader 1 in 22/24 cases. The 95% limits of agreement between the mean digital area measurements and the more precise stereo gradings of Grader 2 were -6.4 % to +6.8 % in the central subfield and -6.0 % to +4.5 % in the middle subfield. The mean absolute differences between the digital and stereo gradings 2 were 2.8 +/- 3.4% in the central subfield and 2.2 +/- 2.7% in the middle subfield. CONCLUSIONS: Semi-automated, supervised drusen measurements may be done reproducibly and accurately with adaptations of commercial software. This technique for macular image analysis has potential for use in clinical research

Cocrystal structure of a class-I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase

Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis selective for the essential nucleobase preQ1 (7-aminomethyl-7-deazaguanine). These reveal a previously unrecognized pseudoknot fold, and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional anti-terminator

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update

This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry

Connectivity-based parcellation of the thalamus explains specific cognitive and behavioural symptoms in patients with bilateral thalamic infarct

A novel approach based on diffusion tractography was used here to characterise the cortico-thalamic connectivity in two patients, both presenting with an isolated bilateral infarct in the thalamus, but exhibiting partially different cognitive and behavioural profiles. Both patients (G.P. and R.F.) had a pervasive deficit in episodic memory, but only one of them (R.F.) suffered also from a dysexecutive syndrome. Both patients had an MRI scan at 3T, including a T1-weighted volume. Their lesions were manually segmented. T1-volumes were normalised to standard space, and the same transformations were applied to the lesion masks. Nineteen healthy controls underwent a diffusion-tensor imaging (DTI) scan. Their DTI data were normalised to standard space and averaged. An atlas of Brodmann areas was used to parcellate the prefrontal cortex. Probabilistic tractography was used to assess the probability of connection between each voxel of the thalamus and a set of prefrontal areas. The resulting map of corticothalamic connections was superimposed onto the patients' lesion masks, to assess whether the location of the thalamic lesions in R.F. (but not in G. P.) implied connections with prefrontal areas involved in dysexecutive syndromes. In G.P., the lesion fell within areas of the thalamus poorly connected with prefrontal areas, showing only a modest probability of connection with the anterior cingulate cortex (ACC). Conversely, R.F.'s lesion fell within thalamic areas extensively connected with the ACC bilaterally, with the right dorsolateral prefrontal cortex, and with the left supplementary motor area. Despite a similar, bilateral involvement of the thalamus, the use of connectivity-based segmentation clarified that R.F.'s lesions only were located within nuclei highly connected with the prefrontal cortical areas, thus explaining the patient's frontal syndrome. This study confirms that DTI tractography is a useful tool to examine in vivo the effect of focal lesions on interconnectivity brain patterns

Beliefs and desires in the predictive brain

Bayesian brain theories suggest that perception, action and cognition arise as animals minimise the mismatch between their expectations and reality. This principle could unify cognitive science with the broader natural sciences, but leave key elements of cognition and behaviour unexplained